Best Numbing Cream For Injections

Peter | 29-12-2025

Looking for some of the best Best Numbing Cream For Injections? As you may know, there are dozens of brands available in the market such as Subleef,Ebanel,WELMATE,NUMSTAT,HealthWise and some come with vastly different price tags. Let us help you out here – we have handpicked the Best Numbing Cream For Injections for you.

To compile our list, we’ve researched and evaluated a range of the best-selling products on the market. We recommend Subleef Best Numbing Cream For Injections as our top pick because of its exceptional overall performance. Want to explore more options? Read on! There’s also a buying guide to help you make a wise shopping decision.

Editor's Choice
Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical
Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical
Premium Pick
WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical
WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical
Budget Pick
NUMSTAT Antiseptic Numbing Wipes for Needle Pain Relief, 2-In-1 Formula with Benzocaine, Isopropyl
NUMSTAT Antiseptic Numbing Wipes for Needle Pain Relief, 2-In-1 Formula with Benzocaine, Isopropyl

Top 10 Best Numbing Cream For Injections

We researched and compared the top products in the Best Numbing Cream For Injections category to provide you with these recommendations.

1. Subleef Deep Numbing Cream Maximum Strength, Long Lasting Topical Anaesthetic Cream Relief Pain

Subleef Deep Numbing Cream Maximum Strength, Long Lasting Topical Anaesthetic Cream Relief Pain
8.9

Subleef

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  • Maximum Strength Active Ingredient: Our topical numbing cream is formulated with the highest non-prescription active ingredient percentage available . It penetrates deep to block nerve signals, providing powerful and effective relief from pain, itching, and burning sensations
  • Gentle & Fast-Acting Formula: Our cream is carefully crafted to be effective yet gentle on the skin. It absorbs quickly to start working where you need it most, providing a soothing barrier that minimizes procedural discomfort.
  • GMP Certified Manufacturing: Every batch is produced under strict Good Manufacturing Practice (GMP) guidelines. This certification is your assurance of a product that meets the highest possible standards for safety, consistency, and quality, trusted by professionals and enthusiasts alike
  • Versatile Pain Relief Cream: This cream is a must-have for anyone undergoing cosmetic or personal care procedures for relief from minor skin irritations, burns, or insect bites . It's trusted by anyone with sensitive skin
  • We are so confident in the power of our numbing cream that we offer a risk-free guarantee if you are among the extremely rare few who do not achieve the desired deep numbing effect.

2. Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical

  • FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
  • 5% Lidocaine Cream Maximum Strength - This pain relief anti itch cream provides immediate relief for minor aches, minor burns, and minor skin irritations. It also works for postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders
  • Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
  • Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal
  • Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing

3. WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical

WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical
9.1

Welmate

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  • Fast Acting Hemorrhoid Cream - Made with 5% Lidocaine, this topical anesthetic provides temporary relief from discomfort, itching, and burning associated with hemorrhoids and other anorectal irritation.
  • Maximum Strength Lidocaine Cream - Delivers doctor-recommended strength with the highest percentage of Lidocaine available over the counter to help soothe targeted external discomfort fast.
  • External Use Only, Made for Sensitive Skin - Formulated for delicate areas, this cream is designed for external, anorectal use and is gentle on all skin types. Packaging is child-resistant for added peace of mind.
  • How to Use - Clean the area with soap and water, rinse thoroughly, and pat dry. Apply external pain relief cream up to 6 times per day. Our cream is cruelty-free, non-greasy, odorless, and free from harsh chemicals.How to Use - Clean the area with soap and water, rinse thoroughly, and pat dry. Apply external pain relief cream up to 6 times per day. Our cream is cruelty-free, non-greasy, odorless, and free from harsh chemicals.
  • Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

4. NUMSTAT Antiseptic Numbing Wipes for Needle Pain Relief, 2-In-1 Formula with Benzocaine, Isopropyl

NUMSTAT Antiseptic Numbing Wipes for Needle Pain Relief, 2-In-1 Formula with Benzocaine, Isopropyl
9.5

Numstat

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  • Relieves Needle Pain - You can now prepare for needle pain with NUMSTAT. If applied in advance to the area, NUMSTATs proprietary blend will be there to relieve the pain with 15% Benzocaine and 1% Menthol, while it cleans and kills germs reducing the risk of infection with 71% Isopropyl Alcohol. Perfect for finger sticks!
  • Fast Acting Antiseptic Prep Wipe for Needle Sticks - Applied in advance to the injection site, NUMSTATs prep pad cleans, kills germs, and relieves the pain of needle sticks with fast-acting Benzocaine. Simply apply the pad solution to the skin, gently rub into the skin for 60 seconds* and let dry. NUMSTAT helps reduce the pain of needle sticks. Test the injection site for effect by touching the area before performing the procedure. May need to reapply on certain skin types.
  • Convenient, Single-Use Prep Pad - NUMSTAT is supplied in convenient individual foil pouches that you can just tear open. The NUMSTAT solution on the non-woven prep pad works fast to prepare the site. It is durable yet soft and non-abrasive to your skin. NUMSTAT can go anywhere and fits in your pocket, purse, travel bag or first-aid kit.
  • Developed by Doctors - Many people are afraid of needles and the pain they bring. Intense fear of needle sticks can cause people to delay or avoid necessary medical care such as diabetic testing. NUMSTAT was developed by doctors to help people with the fear and pain of needle sticks. Applied in advance, NUMSTAT relieves needle pain.
  • How to Use - For adults and children 2 years of age and older, apply to the affected site no more than 4 times daily. Simply apply the pad solution to the skin and gently rub in* and let dry. Use a glove on the application hand or always wash application hand immediately after application. For full directions for use and warnings, please refer to the Drug Facts Label located on the NUMSTAT box.

5. HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy

HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy
8.9

Healthwise

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  • MAXIMUM STRENGTH RELIEF Provides temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backaches, strains, sprains and bruises; apply directly to the skin
  • FAST-ACTING LIDOCAINE Containing 4% lidocaine, this cream works by desensitizing the nerves, effectively numbing the pain where the cream is applied with no irritation and no burning
  • NON-GREASY FORMULA Non-greasy formula glides on smooth; safely apply every 6-8 hours, up to 3x daily
  • SUPPORT AND INSTRUCTION Follow the detailed use instructions, as well as the warnings and cautions, before use; use only as directed, instructions are easy to follow and use
  • Compare to Aspercreme with Lidocaine active ingredients
  • 2.7 oz. bottle (49.6g)

6. WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical

WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical
9.5

Welmate

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  • Fast Acting Hemorrhoid Cream - Made with 5% Lidocaine, this topical anesthetic provides temporary relief from discomfort, itching, and burning associated with hemorrhoids and other anorectal irritation.
  • Maximum Strength Lidocaine Cream - Delivers doctor-recommended strength with the highest percentage of Lidocaine available over the counter to help soothe targeted external discomfort fast.
  • External Use Only, Made for Sensitive Skin - Formulated for delicate areas, this cream is designed for external, anorectal use and is gentle on all skin types. Packaging is child-resistant for added peace of mind.
  • How to Use - Clean the area with soap and water, rinse thoroughly, and pat dry. Apply external pain relief cream up to 6 times per day. Our cream is cruelty-free, non-greasy, odorless, and free from harsh chemicals.
  • Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

7. Acolye Numbing Cream Maximum Strength: 5% Lidocaine Local Anesthetic - Long Lasting with Menthol

  • 5X Numbing : As a 5% lidocaine Numbing cream, it can quickly alleviate minor aches, burns, and skin irritations. It is also effective for hemorrhoid shrinking treatment and anorectal disorders, providing instant relief. It is an ideal choice for relieving localized pain and itching.
  • Fast-Acting and Long-Lasting: This enhanced liposomal deep-penetrating skin numbing cream features optimal efficacy, fast action, and long-lasting effects. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts for 1 hour from its peak. The numbing performance may vary depending on the thickness of the skin area and individual metabolism.
  • Oil-Free, Odor-Free & Non-Greasy: This numbing cream uses a water-based formula that is easy to apply and clean. It is free of harsh chemicals, oil, and has no odor. It leaves no residue before or after use, and is gentle on the skin without causing irritation.
  • Easy to Use: Clean the area to be treated before applying the numbing cream and wait for it to take full effect. It is recommended to conduct a patch test before use to ensure compatibility with your skin. It can be applied before, during, and after treatment, and can be reapplied halfway through for enhanced effect.
  • Effective Healing Properties: This numbing cream contains a blend of powerful ingredients, including Arnica and Emu Oil.

8. Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn

Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn
8

Clinical Resolution

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  • 5% TOPICAL LIDOCAINE PAIN RELIEF 5% Lidocaine Numbing Cream Maximum Strength Topical Pain Relief - This anti burn itch cream provides rapid pain relief for minor aches, minor cuts, minor scrapes, sunburn, scrapes and minor skin irritations. It also works for mosquito bite itch relief, bug bite itch relief, insect bite relief, postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders.
  • LONG LASTING & QUICK RELIEF - Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
  • NON-OILY & NON-GREASY - Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal.
  • FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
  • Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing

9. Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Numb25 Topical

  • FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
  • 5% Lidocaine Cream Maximum Strength - This pain relief anti itch cream provides immediate relief for minor aches, minor burns, and minor skin irritations. It also works for postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders
  • Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
  • Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal
  • Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing

10. Numbing Cream Maximum Strength: Long Lasting Extra Relief with Menthol Arnica and Emu Oil 60ml

Numbing Cream Maximum Strength: Long Lasting Extra Relief with Menthol Arnica and Emu Oil 60ml
7.9

Nupharmco

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  • EXTRA LASTING RELIEF: This numbing cream is provide long-lasting numbing, and relief itching, soreness, burning, and reduce swelling. helps to desensitize the skin, allowing you to feel more comfortable
  • FAST ACTION: We made with special compatibility technology, greatly improving the numbing speed of traditional anesthetic creams. This will reduce your waiting time.
  • EFFECTIVE HEALING PROPERTIES: Our numbing cream contains a blend of powerful ingredients, including Arnica, and Emu Oil, to help speed up the healing process of your skin. This Numbing Cream penetrates the skin to deliver these ingredients, helping to soothe, moisturize, and heal your skin. This means less scabbing and less chance of infection.
  • ODOR-FREE, OIL-FREE & NON-GREASY: Our numbing cream is easy to apply and remove, leaving no mess behind. and contains no harsh chemicals.
  • EASY TO USE: Just wash the area to be treated, apply the numbing cream, and wait for the peak. We recommend patch testing before use to ensure compatibility with your skin.

Peter

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