Best Natural Enzyme Laundry Detergent

Peter | 04-01-2026

With so many great Best Natural Enzyme Laundry Detergent to pick from, like those from brands such as ACTIVE,Dirty Labs,Pronounce,Seventh Generation, it can be tricky for customers to decide what to buy. But after extensive research, we’ve discovered the stand-out Best Natural Enzyme Laundry Detergent currently on the market.

Our team rigorously tested numerous products available to consumers. The one that stands at the top of our list is ACTIVE Best Natural Enzyme Laundry Detergent, thanks to its impressive performance and features. Below you’ll find more of our top-rated picks, along with insightful analysis from our seasoned experts. Check out their thoughts before making your purchasing choice. With this guide backing your decision, you’re sure to end up with a Best Natural Enzyme Laundry Detergent you’ll love.

Editor's Choice
ECOS Laundry Detergent Liquid, 200 Loads - Dermatologist Tested Laundry Soap - Hypoallergenic, EPA
ECOS Laundry Detergent Liquid, 200 Loads - Dermatologist Tested Laundry Soap - Hypoallergenic, EPA
Premium Pick
Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High
Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High
Budget Pick
Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE
Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE

Top 10 Best Natural Enzyme Laundry Detergent

We researched and compared the top products in the Best Natural Enzyme Laundry Detergent category to provide you with these recommendations.

1. Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder,

  • Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
  • Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
  • Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
  • Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
  • Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

2. Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE

  • Concentrated Powder Detergent: ACTIVE Pet Detergent is a Powerful, High Efficiency Compatible Odor Destroyer & Stain Eliminating Detergent. Every Scoop has a Natural Cleaning Power to Handle any Mess, Stain, or Smell left behind by your pet.
  • Suitable for all Pet Laundry: Including Pet Bed, Clothing, Leash, Harness, Blankets, Towels, Furniture Covers & More! ACTIVE is an All-in-One Laundry Detergent Compatible With All Fabric Types, Even Use on your own Clothing and Bedding that smells like your pet!
  • Bio Based Enzyme Cleaner: ACTIVE Enzyme Laundry Detergent is Formulated to Target Pesky Stains and Odors, Including Pet Urine, Cat & Dog Pee, Vomit, Slobber, Dirt, Grime, Oils and Protein Stains. ACTIVE Enzymes even get rid of Wet Dog Odor, and others stubborn scents
  • Natural & Fragrance Free: ACTIVE Pet Detergent is a Natural Laundry Stain Remover, Free of Harsh Chemicals and Gentle for Pets and Sensitive Skin. ACTIVE Actually Removes Odors rather than using scents to cover them up like some alternatives
  • Best Value 64 Loads: Compare ACTIVE Dog Laundry Detergent to liquids that take up more space with less uses. Our Value Pack Comes in a Bulk 2 Lb bag so you can Keep Your Pet Laundry Taken Care Of!
  • Instructions for Use: First, Add 1 to 2 Scoops of ACTIVE Pet Laundry Detergent to your washing machine. Then add your pet laundry or other articles you wish to wash. Finally, start the appropriate washer program for the items you are cleaning. Note: this detergent powder is suitable for all water temperature settings including cold water, but some fabrics may be cleaned more effectively using Warm or Hot water options
  • Troubleshooting Guide: Some heavily soiled laundry items with pet stains or odors present may require extra treatment. We recommend pre-soaking your items in a tub of water, along with 1-2 scoops of detergent, for at least 2 hours. After the pre-soak, simply run through the washing machine like normal. You may also use one scoop of this detergent alongside your preferred laundry detergent for an extra boost of cleaning performance.

3. Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High

Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High
9.1

Dirty Labs

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  • GENTLE: Our formula is consciously formulated with 100% bio and mineral-based ingredients. We left out all the harsh chemicals, fillers, toxins, and pollutants commonly found in other boosters to create a hyperefficient, nontoxic, biodegradable formula. We only use the good stuff so your body and the environment are left as clean as your detergent.
  • EFFECTIVE: Our advanced 4-in-1 formula is the first laundry product in the US to feature a groundbreaking bioenzyme that breaks down tough-to-remove biological stains and odors caused by sweat, body grime, and blood. (Think ring around the collar, yellow pit stains, weird grey or yellow stains on your favorite white sheets, and other stains.)
  • ENVIRONMENTALLY FRIENDLY: At Dirty Labs - Less is More. By creating hyper-concentrated formulas, we greatly reduce our package sizes (and thus, our carbon footprint). Our packaging is made of recyclable cardboard. Our scoop is made from responsibly sourced schima superba wood. Our materials are responsibly sourced and extracted directly from nature. We examine every aspect of our product life cycles in order to achieve the safest, most sustainable solutions.
  • DIRECTIONS: Follow your washer and garment care label instructions. For best results, use with Dirty Labs Bio Laundry Detergents. For standard and HE machines. Septic Safe. 1) Use laundry detergent as you normally would. 2) Add Bio Laundry Booster to wash drum before adding clothes.
  • SPECS: 480 g = 48 loads. Free & Clear (Scent Free). Compatible with traditional and HE washers. Optimized for cold water. No synthetic ingredients. Biodegradable formula. Hypoallergenic and safe for sensitive skin. Safe for babies and pets. Cruelty-free. Vegan. No sulfates. No dyes. No parabens and preservatives. No optical brighteners. No chlorine bleach. No 1,4-dioxane. No fragrance. No CA Prop. 65 chemicals. Packaging and formula are BPA-free.

4. Pronounce Laundry Detergent Powder Alternative | Cleaner Ingredients. Safer for Sensitive Skin.

Pronounce Laundry Detergent Powder Alternative | Cleaner Ingredients. Safer for Sensitive Skin.
8.9

Pronounce

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  • SAFER INGREDIENTS: Pronounce Laundry Powder is made with 5 core ingredients. If you choose one of our scented variations, we only add therapeutic grade essential oils. Pronounce Laundry Powder is free of artificial fragrances, SLS, optical brighteners, parabens, synthetic dyes, or ingredients that dont belong in our homes.
  • 120 LOADS FOR MORE VALUE: Add just one scoop for standard loads and two scoops for heavy soil or large loads. Stop paying for water. Traditional liquid detergent is 80-90% water. By removing this, we are able to achieve 120 loads per bag.
  • SAFER FOR THE ENTIRE FAMILY: Pronounce Laundry Powder was designed to be safer for everyone in the family. Designed for sensitive skin. Available in unscented, as well as three simple scents with only therapeutic grade essential oils.
  • HE WASHER SUITABLE: Pronounce Laundry Powder is suitable for Standard, commercial, and HE washing machines. We utilize a small number of straightforward ingredients with low sudsing properties to create a safer detergent alternative that effectively cleans garments. Septic safe.
  • PACKAGED IN THE USA: We are proud to source nearly every ingredient and component of the product from the United States. Additionally, it is packaged in the United States! A portion of each sale is also donated to clean water charities to provide clean drinking water right here in the United States.

5. Seventh Generation, Laundry Detergent Ultra Power Plus Clean Scent, 23.1 Fl Oz

Seventh Generation, Laundry Detergent Ultra Power Plus Clean Scent, 23.1 Fl Oz
8.7

Seventh Generation

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  • Our Seventh Generation Easy dose auto-dosing technology measures the right detergent amount-every time. Just flip the bottle, give a firm squeeze, and you're done. One squeeze is all you need
  • 6x cleaning agent: a powerful clean that fights even the most stubborn stains with 6 powerful enzymes and surfactants
  • Ultra-concentrated, ultra-convenient laundry detergent: 66 loads in a compact 23oz bottle that's easy to store, and easy to feel good about
  • Small dose, big clean: 60 percent less plastic, 50 percent less water, and 75 percent lighter than our 100 fl oz bottle
  • Safer Choice EPA Certified

6. Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) |

Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) |
8.5

Dirty Labs

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  • GENTLE: Most cleaners today use technologies that were developed almost 100 years ago. In fact, many common deep-cleaning formulas still rely on harmful, petroleum-based chemicals. Dirty Labs is different. Consciously formulated with nontoxic, biobased ingredients, our formulas are safe for sensitive skin and all clothing types. Dirty Labs is cruelty-free, vegan, hypoallergenic, and safe for babies and pets.
  • EFFECTIVE: For us, dirty-free cleaning is not just about clean ingredients. We formulate to get the job done, and we put our products through rigorous testing to ensure theyre strong enough for those who like to get really dirty. Phytolase, our advanced enzyme cleaning technology targets stains and odors at their source while being extra gentle for you, your clothes, and the planet. But don't just take our word for it see what our customers are saying.
  • ENVIRONMENTALLY FRIENDLY: At Dirty Labs - Less is More. By creating hyper-concentrated formulas, we greatly reduce our package sizes (and thus, our carbon footprint). Our bottles are made of aluminum and can be infinitely recycled. Our ingredients are responsibly sourced and created through biorenewable manufacturing processes. We examine every aspect of our product life cycles in order to achieve the safest, most sustainable solutions.
  • DIRECTIONS: Follow your garment care label and washing machine instructions. Measure with teaspoon or Dirty Labs silicone beaker (available separately, or with all 32 load bottles). For tough stains, pretreat directly to soil area and allow to sit for 5 minutes before washing. Our detergent is hyper-concentrated use as follows: 8ml for medium loads, 12ml for large loads, 16 ml for x-large loads.
  • SPECS: 21.6 fl oz = 80 loads. Free & Clear (Scent Free). Compatible with traditional and HE washers. Optimized for cold water. Certified EPA Safer Choice Partner. 97% USDA Biobased certified. No sulfates, dyes, parabens, preservatives, chlorine bleach, or CA Prop.65 Chemicals. Visit our store for more ingredients information.

7. Puracy Laundry Detergent - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry

  • Lasting Laundry Care - Puracy liquid laundry detergent gives you the kind of care you and your family deserve. With a handy 16 oz of laundry concentrate, this pump bottle offers up to 64 loads, enough to clean thoroughly without waste.
  • Plant-Powered Freshness - Powered by plant-based enzymes and minerals, our non-toxic liquid detergent is safe for those with sensitivities. With a free and clear scent trail, your clothes come out of the laundry as fresh as the moments they're worn in.
  • Best for Life's Common Messes - Whether its a splash of chocolate, a drop of grease, or playground mud, our detergent works quietly and effectively, removing persistent stains while you take a moment for yourself.
  • Kind to Most Fabrics - Our detergent cares as much for delicate baby clothes as it does for sturdy denim, treating each fabric with tenderness. Our gentle solution extends the life of your most cherished garments with every wash.
  • Expertly Crafted with Care - Behind every bottle is a team of chemists and PhDs who prioritize your family's safety. Using only mineral and plant-based ingredients, our laundry detergent ensures peace of mind for homes with little ones and furry friends.

8. ECOS Laundry Detergent Liquid, 200 Loads - Dermatologist Tested Laundry Soap - Hypoallergenic, EPA

  • CLIMATE POSITIVE AND SUSTAINABLE - Not only is this laundry detergent formula effective and kind to sensitive skin, but it's also pH-balanced.
  • 100% VEGAN Containing enough detergent for 200 loads of laundry, plant-powered ECOS Laundry Detergent is both cruelty-free and vegan, making it an ideal choice for planet-conscious households.
  • PARABEN AND PHOSPHATE FREE - Unlike most conventional laundry detergents, ECOS does not contain any harsh chemicals or ingredients that can pollute water when it enters the ecosystem.
  • DERMATOLOGIST-TESTED AND HYPOALLERGENIC - ECOS Laundry Detergent is an effective yet gentle cleaning solution for clothes that is suitable for families with skin allergies and sensitivities.
  • MADE IN USA - Proudly made in the USA with globally sourced ingredients
  • CLEAN FORMULAS WITH VISIBLE RESULTS - Since 1967, ECOS has created safer, powerful products by using enzymes found in nature. Our liquid laundry detergents are made in a carbon neutral, water neutral, TRUE Platinum Zero Waste factory using 100% renewable energy.
  • CERTIFIED SAFER CHOICE - Safer Choice certification means that the product perfoms well and contains ingredients that are safer for human health and the environment.
  • BLACK OWNED AND WOMAN LED - ECOS is a Black-owned and woman-led company

9. Charlie’s Soap Laundry Powder New (150 Loads, 1 Pack) Fragrance Free Hypoallergenic Plant Based

Charlie’s Soap Laundry Powder New (150 Loads, 1 Pack) Fragrance Free Hypoallergenic Plant Based
7.9

Charlie's Soap

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  • ECO-FRIENDLY CLEANING POWER: New Convenient 150 load size concentrated powdered laundry soap works on all your laundry, from high-tech fabrics to delicates, washing away smells, stains, and left-behind residue from previous detergents.
  • HYPOALLERGENIC: Washing soda and powerful, natural ingredients work together to deep clean, rinse from fabrics completely, and leave nothing on your clothes. The fragrance-free formula is ideal for those with sensitive skin and will not cover stains or odors with artificial brighteners or perfumes. Our powder laundry detergent is safe for hand washing.
  • CLOTH DIAPER FRIENDLY: This detergent is safe to use on baby fabrics, effectively deep cleaning cloth diapers and other baby clothes between wears perfect along with your other baby essentials.
  • LESS IS MORE: Each bag contains just four ingredients and one tablespoon per dose. No suds, just a deep clean that leaves fabric fresh and soft and your washing machine cleaner by removing old laundry detergents left deep in your machine.
  • EPA SAFER CHOICE CERTIFIED: Charlies Soap laundry soap and our other sustainable products are certified safer for the environment and is septic safe. The eco-friendly formula helps remove fats, oils, greases, and odors from sewer lines, saving your town money and water making it the perfect laundry solution.

10. Molly's Suds Active Wear Laundry Detergent | Extra Strength Sport Laundry Powder, Stain Fighting for

Molly's Suds Active Wear Laundry Detergent | Extra Strength Sport Laundry Powder, Stain Fighting for
7.7

Molly's Suds

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  • EXTRA STRENGTH: Active Wear Detergent is formulated with active enzymes, baking soda and plant-based surfactants (powerful cleaning agents). Specially formulated to fight the sweatiest, smelliest odors and to extend the life of your favorite activewear, athleisure clothing and other high-tech fabrics.
  • SAFER INGREDIENTS: Our formula is safer for those with fragrance sensitivities, sensitive skin, little ones, or other sensitivities. There are no harsh ingredients, synthetic fragrances, dyes, optical brighteners, chlorine, or fillers. The Active Wear Detergent is certified Cruelty-Free by Leaping Bunny.
  • EXTRA CONCENTRATED: This concentrated formula works in all water temperatures and is effective in both hard and soft water. This low sudsing formula is safe for standard and HE washing machines.
  • DESIGNED FOR PERFORMANCE FABRICS: Preserves high-tech features of your performance wear such as breathability, SPF and moisture wicking; ideally-suited for all brands like Adidas, Athleta, Lululemon, Nike, Outdoor Voices and more
  • WHATS INCLUDED: (1) 60 oz (120 load) bag of Active Wear Laundry Detergent with a 1 oz measuring scoop.

Peter

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