Best Methylfolate Supplement

Peter | 03-01-2026

Looking for some of the best Best Methylfolate Supplement? As you may know, there are dozens of brands available in the market such as Triquetra Health,Vitalibre,Nutricost,NOW Foods,Jarrow Formulas and some come with vastly different price tags. Let us help you out here – we have handpicked the Best Methylfolate Supplement for you.

To compile our list, we’ve researched and evaluated a range of the best-selling products on the market. We recommend Triquetra Health Best Methylfolate Supplement as our top pick because of its exceptional overall performance. Want to explore more options? Read on! There’s also a buying guide to help you make a wise shopping decision.

Editor's Choice
THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal
THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal
Premium Pick
NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin,
NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin,
Budget Pick
Vitalibre TMG Supplements, Methyl B Complex, 5-MTHF Folate, B12 Methylcobalamin, TMG
Vitalibre TMG Supplements, Methyl B Complex, 5-MTHF Folate, B12 Methylcobalamin, TMG

Top 10 Best Methylfolate Supplement

We researched and compared the top products in the Best Methylfolate Supplement category to provide you with these recommendations.

1. L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,
9.1

Triquetra Health

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  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

2. L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid
8.9

Triquetra Health

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  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

3. Vitalibre TMG Supplements, Methyl B Complex, 5-MTHF Folate, B12 Methylcobalamin, TMG

Vitalibre TMG Supplements, Methyl B Complex, 5-MTHF Folate, B12 Methylcobalamin, TMG
9.1

Vitalibre

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  • Targeted Homocysteine Support*: Vitalibre TMG Methyl B Vitamins combines Trimethylglycine (TMG)a key methyl donorwith activated B vitamins to help convert homocysteine into methionine, supporting healthy homocysteine levels already within the normal range and promoting heart, brain, and liver health.*
  • Complete Methylation Support*: TMG plays a central role in the bodys methylation process, while the active B vitaminssuch as methyl B12 and methyl folateact as essential cofactors to keep this function running smoothly.* And our formula contains fully methylated and bioactive forms of B vitamins for superior absorption.
  • Cellular Energy & Neurotransmitter Production*: With bioactive B vitamins like riboflavin 5'-phosphate and pyridoxal 5'-phosphate, this complex supports energy metabolism and neurotransmitter synthesishelping to boost vitality and cognitive function at the cellular level.*
  • Made With You In Mind: Combining nature's nutrients with high-quality formulas, we create our first line of clean supplements to help you make confident choices for your health. We are proud to affirm all Vitalibre products are manufactured in the U.S in facilities that adhere to strict Good Manufacturing Practices (GMP) guidelines.
  • High Quality And Value: From meticulously sourcing the finest, most bioavailable ingredients to rigorously testing each formula, the team behind Vitalibre is driven by a relentless pursuit of purity and potency. Putting aside unnecessary fillers and artificial ingredients, were committed to transparency in labeling and providing clear information contains zero sugar, gluten, dairy, soy, wheat, eggs, tree nuts & peanuts.

4. Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO
8.9

Nutricost

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  • 120 Capsules MethylFolate (120 Servings)
  • 1,000mcg MethylFolate Per Serving
  • Vegetarian Capsules
  • Non-GMO & Gluten Free & 3rd Party Tested
  • Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

5. NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin,

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin,
9.5

Now Foods

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  • CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
  • METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968

6. Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports
7.9

Jarrow Formulas

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  • Cellular Energy Metabolism and Cardiovascular support supplement: Contains one 100 count bottle of Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg Chewable Tablets for a 100-day supply.
  • Offers a unique combination of B Vitamins in easy-to-take, lemon-flavored chewable tablets to support cellular energy metabolism, neurotransmitter synthesis and cardiovascular health.
  • Dietary supplement with Methyl B12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
  • Suggested Use: Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional.
  • These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

7. THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal

  • Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
  • Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
  • Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
  • 4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
  • Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

8. Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine
8

Life Extension

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  • Get a brain boost Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognitionespecially as you age.
  • Pump up the heart health This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
  • Metabolically active form 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folates 5-MTHF form.
  • Ingredients matter We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAand a Certificate of Analysis is available for every one.
  • Live your healthiest life We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. Thats why so many of our formulas feature specific ingredients and amounts based on scientific studies.

9. Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and

Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and
8.3

Jarrow Formulas

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  • Cardiovascular and Neurologic Health support supplement: Contains one 60 count bottle of Jarrow Formulas Extra Strength Methyl Folate 400 mcg Veggie Capsules for a 60-day supply
  • Dietary supplement with 400 mcg of Methyl Folate (5-MTHF), a biologically active form of Vitamin B9 to support cardiovascular health, proper cell division and neurologic health*
  • Features Quatrefolic methyl folate that can cross the blood-brain barrier*
  • Suggested Use: Adults, take one capsule once a day with or without food, or as directed by your qualified healthcare professional
  • *These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

10. Horbäach Methyl Folate Supplement | 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid | Non-GMO, Gluten

Horbäach Methyl Folate Supplement | 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid | Non-GMO, Gluten
8.5

Horbäach

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  • ESSENTIAL NUTRIENT: Methyl Folate is the active, more bioavailable form of the B-Vitamin Folic Acid
  • CONVENIENT FORM: Delivers 1000 mcg of this important nutrient in Quick-Release capsules
  • EXPERTLY CRAFTED: Specially formulated supplement derived from high-quality sourcing standards
  • HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Soy, Artificial Color & Flavoring & NON-GMO

Peter

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