Best Knee Pain Relief Spray

Peter | 06-01-2026

With so many Best Knee Pain Relief Spray brands on the market – from big names like Biofreeze,Icy Hot,Aspercreme,Vicks,TIDL to smaller companies – finding the right product can be a real challenge. But we’re here to make your search easier.

We carefully researched and tested a vast range of Best Knee Pain Relief Spray to help you discover the top contenders that match different needs and preferences. Altogether, we spent over 100 hours evaluating numerous products first-hand.

Our #1 best Best Knee Pain Relief Spray is Biofreeze Best Knee Pain Relief Spray, based on its stellar performance across all our tests. Below you’ll find more of our top-rated recommendations for great Best Knee Pain Relief Spray options currently available. Make sure to check out our buying guide too – it’s full of expert advice for choosing a Best Knee Pain Relief Spray tailored to exactly what you’re looking for. With our help guiding your decision, finding your perfect fit will be a breeze!

Editor's Choice
Biofreeze Professional Strength Pain Relief Aerosol Spray, Arthritis Pain Reliever, Knee & Lower
Biofreeze Professional Strength Pain Relief Aerosol Spray, Arthritis Pain Reliever, Knee & Lower
Premium Pick
Aspercreme Lidocaine Dry Spray Soothes Aggravated Nerves, Numbing Topical Pain Relief Spray with
Aspercreme Lidocaine Dry Spray Soothes Aggravated Nerves, Numbing Topical Pain Relief Spray with
Budget Pick
Icy Hot Original Pain Relief Dry Spray, Fast-Acting, Quick-Drying Pain Relief with Max Strength
Icy Hot Original Pain Relief Dry Spray, Fast-Acting, Quick-Drying Pain Relief with Max Strength

Top 10 Best Knee Pain Relief Spray

We researched and compared the top products in the Best Knee Pain Relief Spray category to provide you with these recommendations.

1. Biofreeze Professional Strength Pain Relief Aerosol Spray, Arthritis Pain Reliever, Knee & Lower

Biofreeze Professional Strength Pain Relief Aerosol Spray, Arthritis Pain Reliever, Knee & Lower
9.8

Biofreeze

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  • #1 Clinically Recommended Menthol Topical Pain Relief Brand
  • Biofreeze Professional Pain Relieving Spray applies easily to hard-to-reach areas such as the middle back, neck, and lower extremities
  • Fast acting, cooling menthol formula delivers penetrating pain relief for minor aches and pains of muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains
  • The 4 fl oz 360 spray bottle features the best spray technology available with continuous flow even when upside down
  • Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

2. Icy Hot Original Pain Relief Dry Spray, Fast-Acting, Quick-Drying Pain Relief with Max Strength

Icy Hot Original Pain Relief Dry Spray, Fast-Acting, Quick-Drying Pain Relief with Max Strength
9.5

Icy Hot

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  • INCLUDES: One (1) 4-ounce can of Icy Hot Original Pain Relief Dry Spray
  • POWERFUL RELIEF: Targeted muscle and joint pain relief for backaches; lower back, neck, shoulder, knee, elbow, ankle and leg pain; pain from strains, sprains and bruises; and arthritis pain
  • CONTRAST THERAPY*: A cooling, icy sensation dulls the pain followed by a warming, hot sensation that relaxes it away *Refers to the cooling and warming sensations
  • ACTIVE INGREDIENT: Formulated with the maximum-strength pain-relieving ingredient menthol 16% to target pain receptors
  • FAST-ACTING: The cooling sensation starts working instantly for fast relief from muscle and joint pain
  • NO-MESS APPLICATION: Spray from any angle and target pain with the convenient quick-drying formula
  • ICE & HEAT THERAPY: Ice Works Fast, Heat Makes it Last

3. Biofreeze Menthol Spray 3 FL OZ Colorless Aerosol Spray for Pain Relief associated with Sore

Biofreeze Menthol Spray 3 FL OZ Colorless Aerosol Spray for Pain Relief associated with Sore
9.1

Biofreeze

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  • #1 Clinically Recommended Menthol Topical Pain Relief Brand
  • The 3 fl oz 360 spray bottle features the best spray technology available with continuous flow even when upside down
  • Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

4. Aspercreme Lidocaine Dry Spray Soothes Aggravated Nerves, Numbing Topical Pain Relief Spray with

Aspercreme Lidocaine Dry Spray Soothes Aggravated Nerves, Numbing Topical Pain Relief Spray with
9.8

Aspercreme

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  • Contains one (1) 4-oz. spray bottle of Aspercreme Lidocaine Pain Relief Dry Spray, designed to numb away nerve pain
  • Fast-Acting Relief: Max-strength 4% lidocaine pain relief dry spray targets nerves and numbs away pain
  • Fragrance-Free Formula: Aspercreme pain relief dry spray has no odor for discreet pain relief
  • Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
  • Keeps Hands Clean: Non-greasy Aspercreme pain relief spray dries quickly and works at any angle
  • Aspercreme is the #1 topical lidocaine brand in the U.S.*

5. Vicks VapoFreeze Menthol Pain Relieving Spray 3oz, for Muscles & Joint Pain Associated with

  • PAIN SPRAY: Topical Pain Relief spray for pain beneath the surface, such as joint pain relief, muscle pain relief, knee pain relief, back pain relief, and relief for other muscle aches and pains
  • LONG LASTING PAIN RELIEF: spray for pain relief that lasts for hours, in every easy application of VapoFreeze Joint and Muscle Pain Relief Spray.
  • JOINT PAIN RELIEF: joint pain spray starts working on-contact & penetrates deep beneath the surface for fast joint pain relief
  • FAST BACK PAIN RELIEF: back pain spray targets pain at the source for fast pain relief
  • FOR HARD TO REACH AREAS. VapoFreeze Pain Relieving Spray is easy to apply powerful muscle pain relief & joint pain relief in hard to reach areas
  • MAXIMUM STRENGTH+ FORMULATION: this muscle cream is made with Camphor and Maximum Strength Menthol+ for powerful relief of muscle & joint pain

6. TIDL Cryotherapy Pain Relief Spray, 3 Oz, Targeted Neck Pain, Joint & Muscle Pain Relief, Organic,

  • FAST-ACTING PAIN RELIEF SPRAY: TIDL Pain Relief Spray provides fast-acting, temporary relief from sore muscles, joint pain, backache and arthritis. Great for athletes and active individuals managing daily aches and pains, while supporting recovery and joint health. Helps improve sleep quality and enables a quicker return to regular activities.
  • CRYO-RELIEF PERFORMANCE: TIDL cryotherapy cooling spray combines Arnica and Menthol to deliver rapid cooling relief from muscle pain and joint discomfort. This topical arnica spray with plant-based ingredients boosts recovery, making it ideal for post-training relief.
  • TOTAL BODY RECOVERY: Formulated to complement rigorous training routines, this pain reliever alleviates discomfort neck pain, shoulder pain, hip pain, lower back pain and nerve pain. The fast-acting formula accelerates recovery, helping you return to your active lifestyle quickly. Effective for various types of persistent discomfort when other products may not provide sufficient relief.
  • QUICK-DRYING APPLICATION: This back and body pain reliever provides cooling comfort without stickiness. Its quick-drying formula applies easily over the body with no rubbing required, perfect for pain management on the go. The 360-degree spray technology ensures coverage at any angle. Unlike competing products with harsh chemical odors, TIDL features a pleasant scent that dissipates quickly.
  • BACKED BY SCIENCE: Developed with leading researchers and physicians, TIDL products are formulated for optimal efficacy and safety. TIDL provides pain relief solutions that act as a muscle relaxer to support your active life, helping you get back to doing what you love. Great for on-the-go relief at work, sports events, or travel, this portable solution delivers consistent cooling relief whenever and wherever pain strikes.

7. Icy Hot Lidocaine Pain Relief Dry Spray, Numb Aggravated Nerves with Max Strength Lidocaine 4% and

Icy Hot Lidocaine Pain Relief Dry Spray, Numb Aggravated Nerves with Max Strength Lidocaine 4% and
8.3

Icy Hot

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  • INCLUDES: One (1) 4-ounce can of Icy Hot Lidocaine Pain Relief Dry Spray
  • POWERFUL RELIEF: For the temporary relief of minor pain, including backaches; lower back, neck, shoulder, knee, elbow, ankle and leg pain; pain from strains, sprains and bruises
  • BLOCKS PAIN: Designed to target and numb aggravated nerves to reduce pain signals and provide pain relief
  • ACTIVE INGREDIENT: Formulated with pain-relieving ingredients menthol 1% and maximum-strength lidocaine 4%* *Among OTC topical analgesics for the indicated use(s)
  • FAST-ACTING: Starts working instantly for fast relief from minor pain that you can feel in minutes
  • NO-MESS APPLICATION: Spray from any angle and target pain with the convenient quick-drying formula

8. Biofreeze Professional Pain Relief Spray for Knee, Neck, Hip, Joint, Shoulder, & Simple Backache,

Biofreeze Professional Pain Relief Spray for Knee, Neck, Hip, Joint, Shoulder, & Simple Backache,
8

Biofreeze

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  • #1 Clinically Recommended Menthol Topical Pain Relief Brand
  • Biofreeze Professional Pain Relieving Spray applies easily to hard-to-reach areas such as the middle back, neck, and lower extremities
  • Fast acting, cooling menthol formula delivers penetrating pain relief for minor aches and pains of muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains
  • The 4 fl oz 360 spray bottle features the best spray technology available with continuous flow even when upside down
  • Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

9. AleveX Pain Relieving Spray, Fast Acting & Fast Drying for Targeted Pain Relief, 3.2 oz Spray

  • Powerful Ingredients: Made with Camphor and maximum strength Menthol 16% for powerful topical pain relief
  • Topical Pain Reliever: For the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, sprains, and bruises
  • No Drip, No Mess: Stays where you spray for a convenient alternative to pills
  • Works Fast and Lasts Long: Provides cooling muscle pain relief that won't wear off quickly

10. Stopain Pain Relief Spray 4oz, USA Made, Max Strength Fast Acting with Menthol, MSM, Glucosamine for

Stopain Pain Relief Spray 4oz, USA Made, Max Strength Fast Acting with Menthol, MSM, Glucosamine for
7.7

Stopain

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  • DOES WHAT IT SAYS Stopain maximum strength products dont just reduce or dull; our pain relieving spray STOPS your joint, muscle, and arthritis aches and pains fast
  • IMMEDIATE PENETRATING RELIEF - Soothing menthol topical analgesic free from dyes, fragrances, and preservatives, works on contact and is non-staining and non-greasy, non-irritating and non-allergenic
  • PROVEN TESTED INTEGRITY Made in the USA for 30+ years with the highest quality ingredients, millions of satisfied customers relieved aching muscles, and joints without intolerable heat or icy cold
  • PROFESSIONAL RECOVERY WORKS Pharmacist and healthcare professional recommended products are easy to use and NSAID free with MSM and Glucosamine to support joint flexibility and mobility
  • EXTRA STRENGTH FOR YOUR PAIN Apply our real time pain reliever for sprains, strains, backache, shoulder, knees, hands, wrist or feet; no need for a patch, liniment, cream, hot balm, ointment or ice

Peter

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