Best All Vegetation Killer

Peter | 05-01-2026

Searching for the best Best All Vegetation Killer from top brands like Ortho,RM43,Hi-Yield,VIVIPOOOL, but unsure where to start? We’re here to help. After extensive research, we’ve selected the top Best All Vegetation Killer and also created a buying guide to assist you in choosing the right one.

We evaluated and tested numerous top-rated products to compile this list of standout Best All Vegetation Killer. Our top recommendation is Ortho Best All Vegetation Killer because of its unmatched performance, quality, and value. However, we have more great options below if you want to explore further. Check out our buying guide as well for expert tips on selecting the ideal Best All Vegetation Killer to suit your needs and budget. With our research backing you, finding your perfect match will be easy.

Editor's Choice
RM43 Concentrated Extended Control Weed Killer
RM43 Concentrated Extended Control Weed Killer
Premium Pick
Ortho GroundClear Year Long Vegetation Killer2 Concentrate, Kills and Prevents Weeds Up to 1 Year, 2
Ortho GroundClear Year Long Vegetation Killer2 Concentrate, Kills and Prevents Weeds Up to 1 Year, 2
Budget Pick
Ortho GroundClear Year Long Vegetation Killer Refill, Kills and Prevents Weeds Up to 12 Months, 1
Ortho GroundClear Year Long Vegetation Killer Refill, Kills and Prevents Weeds Up to 12 Months, 1

Top 8 Best All Vegetation Killer

We researched and compared the top products in the Best All Vegetation Killer category to provide you with these recommendations.

1. Ortho GroundClear Year Long Vegetation Killer2 Concentrate, Kills and Prevents Weeds Up to 1 Year, 2

  • Ortho GroundClear Year Long Vegetation Killer2 Concentrate kills weeds, grasses and existing vegetation, and prevents regrowth for up to 1 year
  • The fast-acting weed killer starts working immediately and is rainproof in 1 hour
  • Use this weed control product where no plant growth is wanted for at least a year on driveways, sidewalks, fence lines, paver patios, walkways, gravel areas, parking areas, and other hardscapes
  • Apply this weed killer concentrate by mixing 24 fl. oz. per gallon of water and using a tank sprayer
  • One 2 gal. container of Ortho GroundClear Year Long Vegetation Killer2 Concentrate makes enough product to treat up to 3,200 sq. ft.

2. Ortho GroundClear Year Long Vegetation Killer2 Concentrate, Kills and Prevents Weeds Up to 12

  • Use this weed control product where no plant growth is wanted for at least a year on driveways, sidewalks, fence lines, paver patios, walkways, gravel areas and parking areas
  • This fast-acting weed killer concentrate starts working immediately and kills weeds to the root (when used as directed)
  • Ortho GroundClear Year Long Vegetation Killer2 kills weeds, grasses, and existing vegetation and prevents regrowth for up to 1 year
  • Apply this weed preventer using a tank hose sprayer, mixing 24 fl. oz. of vegetation killer concentrate per gallon of water
  • Add 24 fl oz. of product per 1 gallon of water to treat up to 300 sq. ft

3. RM43 Concentrated Extended Control Weed Killer

  • Concentrated mix with water, add to sprayer
  • Serious Weed Control
  • Up to one year control
  • Total Vegetation control

4. Ortho GroundClear Year Long Vegetation Killer Refill, Kills and Prevents Weeds Up to 12 Months, 1

  • Ortho GroundClear Year Long Vegetation Killer kills weeds, grasses, and all vegetation to the root and prevents weeds and weeds and grasses from growing for up to 1 year
  • Fast acting formula starts working immediately and is rainproof in 1 hour
  • For best results, apply on a sunny day when temperatures are above 60F
  • For use on driveways, sidewalks, fence lines, paver patios, walkways, gravel areas, rock and desert landscapes, under decks, parking areas, cleared dirt, sandy areas, hardscapes and along fences and curbs
  • The refill is convenient and easy to use: remove the existing wand and holster from the original bottle of Ortho GroundClear Year Long Vegetation Killer Ready-to-Use and attach it to GroundClear Year Long Vegetation Killer Refill container

5. Hi-Yield (33692) Super Concentrate Killzall Weed & Grass Killer (32 oz)

Hi-Yield (33692) Super Concentrate Killzall Weed & Grass Killer (32 oz)
7.9

Hi-yield

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  • Weed killer controls grasses, broadleaf weeds and woody brush species. Do not use on lawns.
  • Contains a double-surfactant formulation that dries on plant fast to start working quickly.
  • Allows you to cover and treat large areas. 32 oz. covers up to 6,400 sq ft.
  • 32 oz bottle of weed control liquid concentrate can treat up to 6,400 square feet.
  • See label for application instruction. Spraying accessory required for application.

6. 1 Gallon 41% Glyphosate Super Concentrate Weed & Grass Killer

1 Gallon 41% Glyphosate Super Concentrate Weed & Grass Killer
8.3

Vivipoool

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  • Powerful Weed Control:Effectively kills over 130 types of weeds and grasses, reaching down to the roots to prevent regrowth. Perfect for driveways, sidewalks, fences, and garden areas.
  • Covers Up To 26,000 Square Feet
  • Broad-spectrum systemic herbicideWeeds begin to yellow in 5-8 dayscompletely dead in 9-15 days.
  • Eco-Friendly & Safe:Please read the usage instructions carefully before use, protecting both the environment and your family.
  • Versatile Application:Suitable for home, commercial, and agricultural use. Ideal for lawns, gardens, orchards, and more, helping you maintain a clean and tidy outdoor space with ease.

7. Hi-Yield (32170) Killzall 365 (32 oz)

Hi-Yield (32170) Killzall 365 (32 oz)
8.7

Hi-yield

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  • Controls unwanted weeds and other vegetation on non-crop/no-vegetation areas. Do not use on lawns.
  • Kills a variety of broadleaf weeds, grasses, trees, brush and vine species. See label for full list.
  • This 32 oz bottle of weed killer liquid concentrate treats up to 4,300 square feet.
  • For spot control of brush, vines and weeds mix 6 oz of concentrate per 1 gal of water.
  • Mix 7.4 oz with 1 to 10 gal of water and spray where vegetation control and bare ground is desired.

8. Roundup Weed and Grass Killerâ‚„ with Pump 'N Go 2 Sprayer, Use in and Around Flower Beds, Trees &

Roundup Weed and Grass Killerâ‚„ with Pump 'N Go 2 Sprayer, Use in and Around Flower Beds, Trees &
8.9

Roundup

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  • Roundup Weed & Grass Killer kills tough weeds and grasses to the root, including dandelion, crabgrass, poison ivy, clover (red & white), spotted spurge, and other broadleaf weeds
  • It is rainproof in as fast as 30 minutes and produces visible results in hours
  • Allows for planting 1 to 30 days after application (see booklet for details)
  • Use in or around flower beds and perennial landscape plants, around trees and shrubs, on patios, walkways, and driveways, gravel, or mulch beds, along fences and foundations, and edging around foundations and retaining walls
  • The Pump N Go 2 Sprayer with an extendable wand provides up to 10 minutes of continuous spray and provides greater accuracy without bending over

Peter

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