Best Mthfr Multivitamin

Peter | 05-01-2026

With so many Best Mthfr Multivitamin brands on the market – from prominent names like Micro Ingredients,PD VARS,Pure Therapro Rx,Double Wood Supplements,Pure Encapsulations to smaller manufacturers – making the right choice can feel overwhelming. But we’re here to help simplify your search for the best product.

We extensively tested and evaluated dozens of top-rated Best Mthfr Multivitamin across various price points, spending over 100 hours comparing the contenders side-by-side. Based on our in-depth first-hand research, we compiled this list of stand-out Best Mthfr Multivitamin to consider. Our top recommendation is Micro Ingredients Best Mthfr Multivitamin for its uncompromising quality and performance.

Below you’ll discover more of our favorite Best Mthfr Multivitamin picks. And be sure to consult our buying guide for expert insights on selecting the ideal product for your individual needs and budget. With us guiding your decision, you can shop confidently knowing you’ve chosen an exceptional Best Mthfr Multivitamin you’ll truly love.

Editor's Choice
Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy,
Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy,
Premium Pick
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,
Budget Pick
Pure Therapro Rx Methylated Multivitamin for Men and Women | Made in USA | Methyl Multi Without Iron
Pure Therapro Rx Methylated Multivitamin for Men and Women | Made in USA | Methyl Multi Without Iron

Top 10 Best Mthfr Multivitamin

We researched and compared the top products in the Best Mthfr Multivitamin category to provide you with these recommendations.

1. Micro Ingredients Pure Methylated Multivitamin, 240 Capsules | 19-in-1 Formula with Vitamins C, D,

Micro Ingredients Pure Methylated Multivitamin, 240 Capsules | 19-in-1 Formula with Vitamins C, D,
7.7

Micro Ingredients

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  • Micro Ingredients offers a Pure Methylated Multivitamin Complex. 19-in-1 support with high absorption bioactive forms. 240 capsules that feature raw, active ingredients with no fillers.
  • Each serving provides active methylated vitamins like fat-soluble vitamin C (ascorbyl palmitate), A (retinyl palmitate), D3 (cholecalciferol), E (d- alpha tocopherol), thiamin HCl, riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate, B12 (methylcobalamin), biotin, and pantothenic acid.
  • An advanced multivitamin combined with key minerals for promoting various health benefits that include energy, cellular, heart, immune, and brain support for men and women*.
  • Enjoy only active ingredients that use high bioavailable methylated vitamins and minerals for efficiently refilling key nutritional gaps over time.
  • Premium non-GMO multivitamins supplement. Made without fillers, soy, dairy, wheat, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent.

2. Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy,

Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy,
9.8

Pd Vars

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  • YOUR DAILY ALLY IN GENETIC HEALTH - MTHFR Daily Multivitamin is crafted to support those with MTHFR gene variations. Our formula blends vital nutrients and minerals to enhance methylation, aid detoxification, and boost overall wellness, including a complete Vitamin B complex for comprehensive support.
  • WHY MTHFR DAILY STANDS OUT - For those with MTHFR genetic errors, the body's ability to process certain B vitamins into their active forms is compromised, affecting DNA repair, detoxification, and neurotransmitter production. Our methylated multivitamin tackles these challenges for optimal absorption and effectiveness.
  • KEY INGREDIENTS - Our MTHFR multivitamin formula includes L-5-Methyltetrahydrofolate (5-MTHF) for improved folate processing. In addition, it contains Vitamin B12 for energy and focus, Vitamin B2 to enhance MTHF enzyme function, and Vitamin B5 for adrenal health and energy production, crucial for stress management.
  • ALL-AROUND SUPPORT - This methylated multivitamin for men & women includes a complete Vitamin B-complex and is packed with essential vitamins & minerals like Magnesium, Zinc, Selenium, Manganese, Choline, Inositol, and Alpha Lipoic Acid, to address common deficiencies and support holistic health.
  • BENEFITS - MTHFR Daily supports your body's natural methylation pathways for enhanced vitality. B vitamins boost energy and nerve health, minerals aid enzymatic functions & antioxidant defenses, while specialty nutrients enhance liver, cognitive, and cellular health. Experience improved energy, mental clarity, mood, and overall wellness!

3. Pure Therapro Rx Methylated Multivitamin for Men and Women | Made in USA | Methyl Multi Without Iron

Pure Therapro Rx Methylated Multivitamin for Men and Women | Made in USA | Methyl Multi Without Iron
9.1

Pure Therapro Rx

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  • : Discussed on The Joe Rogan Experience with Gary Brecka, our Methyl Multi without Iron is a vegan-friendly, hypoallergenic, and meticulously-researched multivitamin and multimineral supplement made from high-quality ingredients with zero fillers. Our comprehensive formulation promotes healthy cognitive function and supports antioxidant protection and detoxication. Methyl Multi is the ultimate multivitamin to support total-body wellness and optimum vitality.
  • : When supplementing, absorption is key! Methyl Multi without Iron is formulated with Quatrefolic Folate (5-MTHF), Albion TRAACS mineral chelates, and other micronutrients in their pre-methylated and coenzyme forms for optimal absorption and bioavailability, all together in patented EMBOCAPS AP60 acid resistant vegetable capsules designed for a guaranteed 60 minutes of acid-protection.
  • : Millions of Americans have MTHFR and/or COMT mutations, making it difficult for their bodies to process key vitamins like B12 and Folate. Methyl Multi without Iron contains pre-methylated forms of B12 and Folate for increased bioavailability, which can help to support healthy metabolism, energy release from food, detoxification, and nervous system function.
  • ? For those extremely sensitive or new to methylated vitamins, we recommend gradually increasing the amount you are taking so your body can adapt. A small percentage of customers can experience a temporary detoxification / Herxheimer response. Symptoms may include: headache, lethargy, skin rash / hives, respiratory symptoms (cough, sore throat). These are temporary and a sign that the supplement is working. However if your body detoxes too quickly at one time it can overload your detox pathways! Its imperative to lower the amount you are taking for a few days and work your way up slowly to the full dose LOW & SLOW
  • : Pure TheraPro Rx Methyl Multi without Iron contain no fillers such as rice flour, cornstarch, or wood pulp fibers. Our manufacturing facility adheres to strict NSF/cGMP guidelines. Consumer safety and satisfaction are our highest priority, which is why our products undergo rigorous third-party testing and screening to ensure product purity and potency.
  • : Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.

4. Methylated Multivitamin (Methylated and Activated Vitamins Only - Methylated B Complex with

Methylated Multivitamin (Methylated and Activated Vitamins Only - Methylated B Complex with
8.9

Double Wood Supplements

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  • METHYLATED FORMS OF VITAMINS: Double Wood's Methylated Multivitamin contains only methylated / activated forms of vitamins that are already usable by the body and do not need to be further converted in order to be bioavailable
  • METHYLATED B COMPLEX: Contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcobalamin and Dibencozide)(Methyl B12)
  • SIX TOTAL METHYLATED VITAMINS: Contains trimethylglycine and calcium L-5-methyltetrahydrofolate (MTHFR multivitamin) to help support healthy folic acid levels and control homocysteine levels in the body. It is important to use methylated folic acid since standard folic acid is inert in the body and cannot be processed further by many people
  • CAN COMBINE WITH A NORMAL MULTIVITAMIN: Double Wood's Methylated Multivitamin can be combined with a regular multivitamin for those looking to also supplement with inactive vitamins or vitamins such as Magnesium and Vitamin D
  • WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

5. Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex
8.5

Pure Encapsulations

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  • Multivitamin for Women & Men: Once-daily capsules provides vitamins A, B, C, D and E in highly bioavailable forms; CoQ10, L-5-MTHF, and ALA for antioxidant support*
  • Cognitive Support Multivitamin: O.N.E. Multivitamin provides choline, inositol, lycopene, vitamin D, lutein, and zeaxanthin for overall wellness*
  • Natural Color Variation: O.N.E. Multivitamin has a distinct odor/taste; moisture can create a spotted appearance that is normal and safe to use*
  • Pure Encapsulations O.N.E. Vitamins: These multivitamins for men and women support healthy cognitive function, cellular health, and eye health*
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

6. Micro Ingredients Pure Methylated Multivitamin for Women, 240 Capsules | 32-in-1 Formula with

Micro Ingredients Pure Methylated Multivitamin for Women, 240 Capsules | 32-in-1 Formula with
8.5

Micro Ingredients

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  • Micro Ingredients offers a Pure Methylated Multivitamin for Women. Features 32 essential nutrients and superfoods with high absorption bioactive forms. 240 capsules made with clean, active ingredients and no fillers.
  • Each serving provides activated methylated vitamins like fat-soluble vitamin C (ascorbyl palmitate), A (retinyl palmitate), D3 (cholecalciferol), E (d-alpha tocopherol), thiamine (as thiamin mononitrate), riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate (L-5-MTHF), B12 (methylcobalamin), biotin, and pantothenic acid.
  • An advanced adult womens multivitamin combined with essential minerals such as iron, magnesium, zinc, selenium, calcium, iodine, copper, and chromium, plus inositol and a specialized womens blend including chasteberry, cranberry, ashwagandha, pomegranate, dong quai, and hydrolyzed collagen peptides.
  • Enjoy only clean ingredients that provide daily hormonal support, as well as lasting energy, immune function, bone strength, skin health, and overall vitality for women at every stage of life.
  • Premium non-GMO multivitamins supplement. Made without fillers, soy, dairy, wheat, gluten, and tree nuts. Ingredients must pass a 3rd party lab test to ensure our product is safe, pure, and potent.

7. L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood,
9.1

Triquetra Health

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  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

8. NatureGenX Just One Daily Methylated Multivitamin - 60 Caps Pure Methyl B12, Methylfolate MTHFR

NatureGenX Just One Daily Methylated Multivitamin - 60 Caps Pure Methyl B12, Methylfolate MTHFR
8

Naturegenx

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  • FORMULATED FOR ABSORPTION: Experience superior nutrient absorption with our one a day multivitamin featuring body-ready methylated vitamins, perfect for everyone including those known MTHFR gene mutation. Efficient methylation, no conversion needed, activating instantly in your body to effortlessly fill your daily nutrient needs.
  • 2 MONTHS SUPPLY BALANCED WELL-BEING WITH IRON-FREE MULTIVITAMINS FOR ADULTS; MEN & WOMEN: Unlock a healthier you with our 60-capsule, 2-month supply of NatureGenX Methylated Multivitamin. packs 27 nutrients to fill modern diet gaps and conveniently helps bone, immune, metabolic, antioxidant and cardiovascular health - giving you complete, balanced nutrition in just one capsule.
  • BIOAVAILABLE METHYLFOLATE FOR HOMOCYSTEINE BALANCE: Our MTHFR multivitamin without folic acid boasts Choline, methyl folate (5-MTHF), Methyl B12, B6, and other methylated B vitamins. This combination supports a healthy homocysteine balance and metabolism, contributing to overall wellness.
  • USA-MADE & QUALITY ASSURANCE: Rest easy knowing NatureGenX Methylated Multivitamin is proudly made in the USA in an NSF/GMP facility. Soy-free and gluten-free, it adheres to the highest safety standards. Unlike some imported products "Packaged in the USA", we ensure integrity every step of the way for your peace of mind.
  • EMBRACE NATURAL VARIATION - PURE AND UNADULTERATED: NatureGenX preserves authenticity by refraining from artificial additives. Bioactive vitamins may exhibit a natural odor due to oxidation, while speckles result from chelated minerals that enhance absorption both entirely normal. Store in a sealed, moisture-free space or refrigerate to minimize scent and maintain product freshness.

9. Seeking Health Multivitamin One - Supplement with Zinc, Vitamin B12, & Vitamin A - Magnesium-Free

Seeking Health Multivitamin One - Supplement with Zinc, Vitamin B12, & Vitamin A - Magnesium-Free
7.9

Seeking Health

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  • Methylfolate & Zinc Supplement: This multivitamin is made with a bioavailable form of vitamin B12 and zinc to support optimal methylation and healthy immune function
  • Multivitamin Supplement with Antioxidants: This multivitamin has PQQ, SOD, and vitamin E to support healthy aging and immune health
  • Supplement with Vitamins & Minerals: This multivitamin is made with bioavailable nutrients to support energy production and healthy stress responses
  • Allergen-Friendly Multivitamin Support: This multivitamin supplement is free of GMOs, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
  • Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

10. Igennus High Potency Methylated Multivitamin for Women, Pure & Clean Ingredients, MTHFR Supplement

Igennus High Potency Methylated Multivitamin for Women, Pure & Clean Ingredients, MTHFR Supplement
7.7

Igennus Healthcare Nutrition

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  • METHYLATED & ACTIVE FORMS each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals, gentle iron and zinc (new label, same advanced formula, you may receive either label)*
  • PURE & CLEAN vegan, non-GMO, hypoallergenic & lab-verified ingredients with no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). GMP manufactured in the UK
  • HIGH POTENCY we have boosted levels of iron, B-vitamins, vitamin D and zinc in ratios that work in balance with the body. Provides enhanced support for energy, immunity, hormone balance and mood. Supplementing with iron may not be suitable for postmenopausal women*
  • MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for women of menstruating age, topping up nutrients often lacking in everyday diets, without unnecessary extras*
  • ALL-DAY COVERAGE this high-absorption formula is enhanced with sustained release delivery, optimizing blood nutrient levels for maximum health benefits and peace of mind. Take two, small tablets daily

Peter

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