Best Systemic Multi-enzyme Therapy

Peter | 03-12-2025

With so many great Best Systemic Multi-enzyme Therapy to pick from, like those from brands such as Carlyle,WellnessOne,VITÄLZYM,VitaBoost,AST Enzymes, it can be tricky for customers to decide what to buy. But after extensive research, we’ve discovered the stand-out Best Systemic Multi-enzyme Therapy currently on the market.

Our team rigorously tested numerous products available to consumers. The one that stands at the top of our list is Carlyle Best Systemic Multi-enzyme Therapy, thanks to its impressive performance and features. Below you’ll find more of our top-rated picks, along with insightful analysis from our seasoned experts. Check out their thoughts before making your purchasing choice. With this guide backing your decision, you’re sure to end up with a Best Systemic Multi-enzyme Therapy you’ll love.

Editor's Choice
WellnessOne Proteolytic Enzymes Supplements w/ Nattokinase & Seapose - Pro-OneZyme Systemic
WellnessOne Proteolytic Enzymes Supplements w/ Nattokinase & Seapose - Pro-OneZyme Systemic
Premium Pick
Systemic Formulas MIN #140 Multi Mineral Plus – 60 Capsules | Essential Mineral Complex for Daily
Systemic Formulas MIN #140 Multi Mineral Plus – 60 Capsules | Essential Mineral Complex for Daily
Budget Pick
Serracor-NK – 300 Vegetarian Capsules – Circulatory and Respiratory Support – Natural Systemic
Serracor-NK – 300 Vegetarian Capsules – Circulatory and Respiratory Support – Natural Systemic

Top 10 Best Systemic Multi-enzyme Therapy

We researched and compared the top products in the Best Systemic Multi-enzyme Therapy category to provide you with these recommendations.

1. Carlyle Proteolytic Enzymes | 300 Capsules | Systemic Broad Spectrum Supplement | Vegetarian,

Carlyle Proteolytic Enzymes | 300 Capsules | Systemic Broad Spectrum Supplement | Vegetarian,
7.9

Carlyle

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  • PROTEOLYTIC ENZYMES: Can be found naturally in certain foods like papaya and pineapple
  • BROAD SPECTRUM: Features an Advanced Enzyme Complex with Premium Turmeric Curcumin for added support
  • ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
  • CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Sweetener, Preservatives & Non-GMO

2. WellnessOne Proteolytic Enzymes Supplements w/ Nattokinase & Seapose - Pro-OneZyme Systemic

WellnessOne Proteolytic Enzymes Supplements w/ Nattokinase & Seapose - Pro-OneZyme Systemic
8.9

Wellnessone

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  • - ProOneZyme is the only supplement that contains 6 of the best quality proteolytic enzymes in one convenient enzymes proteolytic vegan capsule. These ingredients include Bromelain, Nattokinase, Papain, Peptidase, Protease, Seaprose, Catalase and Rutin
  • - Proteolytic enzyme contains no wheat, yeast, soy or gluten. NO animal derivatives, sugars, artificial flavors, colors or fillers. Systemic and proteolytic enzymes are perfect for vegetarians and meat lovers alike!
  • - Proteolytic Systemic Enzymes gives active enzymes the body can use. They can also work in part to help digest food & are a proteolytic boost for inflamed joints. When the body is happy, you feel younger and full of life.
  • - Nattokinase and Seaprose are gentle on the stomach. ProOneZyme proteolytic enzyme capsules are designed to withstand stomach acid and release inside the intestinal tract where it is absorbed and used in the body.
  • % ! If for any reason you are not satisfied with ProOneZyme, simply return any unused portion for a full no hassle, 30-Day Money-Back Guarantee! Third Party Tested and manufactured in a GMP Facility.

3. VITÄLZYM Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source | Immune and

VITÄLZYM Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source | Immune and
8.3

VitÄlzym

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  • American Made, Essential for Health, Plant Based: Not All Complete Digestive System Enzyme Products Are Made The Same - Pay For True Quality & You Will Not Be Disappointed. World Nutrition is a pioneer of complementary systemic enzymes. In 2001 we introduced the original Vitalzym pill as a hybrid formula that offers both systemic & digestive benefits to provide total body support. It quickly became the best-selling systemic enzyme in the world and sold over $10M in the first 3 years alone
  • The Best Vegetarian Digestion Supplement & Remedy: Our Premium Strength Super Gut Defense Formula contains everything you need for full-body support: Protease, Serrapeptase, Papain, Bromelain, Amylase, Lipase, Rutin, & Amla. Each powerful ingredient is derived from natural, vegetarian sources. Most competitors use enzymes harvested from pigs & cows after slaughter. These enzymes are low-quality & strength, requiring a much higher dose as theyre less effective against targeted mediators
  • Advanced, Broad Spectrum Caps Promote Wellness: Our complex extract provides the optimal potency level of proteolytic enzymes that may assist with IBS, gas, inflammation, regulating your immune system, removing excess plaque & fibrin (fibrous tissue), & support the return of blood volume & flow. Vitlzym capsules are formulated to support health in the following systems: cognitive/mental, upper respiratory, cardiovascular, gastrointestinal, reproductive, joints, connective tissue, & skin
  • Fast Response, Organic, Calms Indigestion & Assists With IBS, Gas, Bloating: Regain bowel comfort with our perfect synergistic blend of systemic and digestive enzymes. It starts in the stomach & helps the body to break down food and absorb nutrients. After helping increase digestive abilities, the systemic enzymes take action in the bloodstream, moving throughout your entire body. This unique combination can help to improve your bodily processes and regain your quality of life
  • Formulated for Active Vitality Enhancement Plus Recovery: High-quality pure powder filled capsules that break down in your stomach provide digestive support with every dose. Some serrapeptase survives the acidic environment of the stomach and a dosage is released in the small intestine, allowing it to be absorbed into your bloodstream and distributed throughout your whole body. Our customers have reported increased energy, stamina, and recovery from intense exercise

4. Systemic Formulas MIN #140 Multi Mineral Plus – 60 Capsules | Essential Mineral Complex for Daily

Systemic Formulas MIN #140 Multi Mineral Plus – 60 Capsules | Essential Mineral Complex for Daily
8.9

Vitaboost

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  • Comprehensive Mineral Support delivers a spectrum of essential macro and trace minerals that may help promote cellular energy, enzyme function, and internal balance
  • Bioavailable & Gentle on Digestion formulated with easily absorbed mineral forms to optimize uptake while being easy on sensitive stomachs
  • Supports Hydration & Electrolyte Balance includes minerals like magnesium and potassium which may help maintain hydration, especially in active individuals
  • Clean, Professional-Grade Formula free from gluten, dairy, soy, artificial colors, and preservatives for a natural and effective daily supplement

5. Serracor-NK – 300 Vegetarian Capsules – Circulatory and Respiratory Support – Natural Systemic

Serracor-NK – 300 Vegetarian Capsules – Circulatory and Respiratory Support – Natural Systemic
8.7

Ast Enzymes

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  • Advanced systemic enzyme formula: Serracor-NK is a powerful blend of Acid-Resistant Serrapeptase and Nattokinase, systemic enzymes studied for their fibrinolytic properties, with herbs, CoEnzyme Q10 and magnesium.*
  • Achieve: The combination of Serrapeptase and Nattokinase used in addition to a complete array of proteolytic enzymes, makes Serracor-NK a unique blend designed to support well-being and circulation*
  • Quality Assured: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.

6. AST Enzymes Serrapeptase 80,000 SPU – 120 Vegetarian Capsules - Premium Natural Systemic Enzymes

AST Enzymes Serrapeptase 80,000 SPU – 120 Vegetarian Capsules - Premium Natural Systemic Enzymes
8.5

Ast Enzymes

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  • ADVANCED SYSTEMIC ENZYME: Serrapeptase (known as Serratiopeptidase) is a powerful, proteolytic enzyme derived from silkworms known for its fibrinolytic properties (to support normal fibrin metabolism).*
  • ACID-RESISTANT: Our Serrapeptase has a completely phthalate-free polymer applied to maximize efficacy.*
  • RANGE OF USE: Promotes beneficial immune cell response, and healthy respiratory and sinus function. Supports muscle, joint, and overall body/tissue health.*
  • ACHIEVE OPTIMUM HEALTH NATURALLY: An all-natural enzyme such as Serrapeptase, supports a healthy response to inflammation to restore balance.*
  • QUALITY ASSURED & ALLERGEN FRIENDLY: All products by AST Enzymes are manufactured in the USA. Free of wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish, and sesame.

7. AST Enzymes Serrapeptase 80,000 SPU – 300 Vegetarian Capsules - Premium Natural Systemic Enzymes

AST Enzymes Serrapeptase 80,000 SPU – 300 Vegetarian Capsules - Premium Natural Systemic Enzymes
8.3

Ast Enzymes

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  • ADVANCED SYSTEMIC ENZYME: Serrapeptase (known as Serratiopeptidase) is a powerful, proteolytic enzyme derived from silkworms known for its fibrinolytic properties (to support normal fibrin metabolism).*
  • ACID-RESISTANT: Our Serrapeptase has a completely phthalate-free polymer applied to maximize efficacy.*
  • RANGE OF USE: Promotes beneficial immune cell response, and healthy respiratory and sinus function. Supports muscle, joint, and overall body/tissue health.*
  • ACHIEVE OPTIMUM HEALTH NATURALLY: An all-natural enzyme such as Serrapeptase supports a healthy response to inflammation to restore balance.*
  • QUALITY ASSURED & ALLERGEN FRIENDLY: All products by AST Enzymes are manufactured in the USA. Free of wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish, and sesame.

8. AST Enzymes Serrapeptase 130,000 SPU – 60 Vegetarian Capsules – Premium Natural Systemic Enzymes

AST Enzymes Serrapeptase 130,000 SPU – 60 Vegetarian Capsules – Premium Natural Systemic Enzymes
8

Ast Enzymes

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  • ADVANCED SYSTEMIC ENZYME: Serrapeptase (known as Serratiopeptidase) is a powerful, proteolytic enzyme derived from silkworms known for its fibrinolytic properties (to support normal fibrin metabolism).* With 130,000 SPU, it is one of the strongest on the market.*
  • ACID-RESISTANT: Our Serrapeptase has a completely phthalate-free polymer applied to maximize efficacy.*
  • RANGE OF USE: Promotes beneficial immune cell response, and healthy respiratory and sinus function. Supports muscle, joint, and overall body/tissue health.*
  • ACHIEVE OPTIMUM HEALTH NATURALLY: An all-natural enzyme such as Serrapeptase supports a healthy response to inflammation to restore balance.*
  • QUALITY ASSURED & ALLERGEN FRIENDLY: All products by AST Enzymes are manufactured in the USA. Free of wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish, and sesame.

9. Systemic Formulas MIN Multi Mineral Plus - 60 Capsules (Pack of 2) Comprehensive Mineral Support for

Systemic Formulas MIN Multi Mineral Plus - 60 Capsules (Pack of 2) Comprehensive Mineral Support for
7.9

Generic

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10. Global Healing - Ultimate Enzymes - Systemic & Digestive Enzymes Supplement for Healthy Digestion,

Global Healing - Ultimate Enzymes - Systemic & Digestive Enzymes Supplement for Healthy Digestion,
7.7

Global Healing Center

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  • VeganZyme is the most advanced, full-spectrum, systemic and digestive enzyme supplement in the world
  • Contains the broadest spectrum of vegetarian-based enzymes available anywhere
  • Provides systemic enzyme support to break down excess mucus and toxins throughout your body
  • Helps your body digest fats, sugars, proteins, carbohydrates, gluten, fruits and vegetables, cereals, legumes, bran, nuts and seeds, soy, dairy and other foods

Peter

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